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It is, however, very effective in the treatment of sleep-maintenance insomnia, especially in patients with comorbid mental disorders or patients treated with activating antidepressants.. This activity reviews the indications, action, and contraindications for trazodone as a valuable agent in managing major depression. Comments: Patients should be screened for a personal/family history of bipolar disorder, mania, or hypomania prior to initiating treatment Trazodone is a prescription medication that has been used to treat depression disorders and sleep disorders. [23] [24] Contents 1 Medical uses 1. Trazodone is a medication used in the management and treatment of major depressive disorder. IsHak is with the Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, California, and the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. To save this book to your Kindle, first ensure coreplatform@cambridge. Find out how trazodone treats depression and anxiety and how to take it. 1 No products are labeled for veterinary use.. It’s available only as a generic drug. For sleep problems, doctors typically prescribe low doses of trazodone, between 25 and 100 milligrams (mg). 1–3 It is available in 50-, 100-, 150-, and 300-mg tablets as well as 150- and 300-mg extended-release tablets. 8 – 10 Given this widespread use, it seems beneficial to evaluate the literature on the efficacy and safety of trazodone when administered for the treatment of insomnia Insomnia is the most frequent reason for prescription of trazodone. Trazodone oral tablet is a prescription drug. About trazodone Who can and cannot take it How and when to take it Side effects Pregnancy, breastfeeding and fertility Taking trazodone with other medicines and herbal supplements Common questions Related conditions Clinical depression. 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