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I would stop the use and the redness/ swelling would go away and i would contine use and everything would be okay Imiquimod, a topical immune response modifier, belongs to the family of immunostimulators. Not known: Like most other wart creams there is no definative answer to how many applications will get rid of the wart. I would stop the use and the redness/ swelling would go away and i …. 6 out of 5 - 16445 reviews When applied directly to the genital warts, Aldara cream is a medication that works by helping your body’s own immune system to produce natural substances which help fight the HPV virus that has caused your warts. Aldara cream contains imiquimod 5%, which acts by stimulating the body's own defence mechanisms. Your skin is likely to become red, swollen and sore at the site of application within 5 days of starting treatment. Imiquimod can either be used alone or in combination. How does aldara cream of the medicine work? Interferon is also used as a cancer treatment. 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